TAT-cyclo-CLLFVY
TAT-cyclo-CLLFVY
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TAT-cyclo-CLLFVY

SKU TP2046-1 mg Category Brand:

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Products Details

Product Description

– Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.

Web ID

– TP2046

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C111H188N42O24S2

References

– Miranda et al (2013) A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J.Am.Chem.Soc. 135 10418 PMID:

CAS Number

– 1446322-66-2

Molecular Weight

– C111H188N42O24S2

SMILES

– C(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CSSC[C@@H]2NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H]([C@@H](C)C)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC2=O)N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC1)N5[C@H](C(N[C@@H](CCC(N)=O)C(O)=O)=O)CCC5

Product type

– Peptide

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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