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TAPI-2
SKU
HY-100211-1 mg
Category Reference compound
Tags Anti-infection;Metabolic Enzyme/Protease, Cancer, MMP;SARS-CoV
$198 – $1,254
Products Details
Product Description
– TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP[1]. TAPI-2 blocks the entry of infectious SARS-CoV[2].
Web ID
– HY-100211
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C19H37N5O5
References
– [1]Kruse MN, et al. Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors. Biochem J. 2004 Mar 1;378(Pt 2):383-9.|[2]Wang R, et al. A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling. Stem Cells Transl Med. 2016 Mar;5(3):331-8.|[3]Shiori Haga, et al. TACE Antagonists Blocking ACE2 Shedding Caused by the Spike Protein of SARS-CoV Are Candidate Antiviral Compounds. Antiviral Res. 2010 Mar;85(3):551-5.
CAS Number
– 187034-31-7
Molecular Weight
– 415.53
Compound Purity
– 99.46
SMILES
– CC(C)(C)[C@@H](C(N[C@H](C(NCCN)=O)C)=O)NC(C(CC(NO)=O)CC(C)C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 22 mg/mL|Ethanol : 50 mg/mL (warming)|H2O : 100 mg/mL (ultrasonic)
Target
– MMP;SARS-CoV
Isoform
– MMP
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
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