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Tamoxifen
Price range: 48 CAD through 302 CAD
Products Details
Product Description
– Tamoxifen (ICI47699) is a selective and orally effective estrogen receptor modulator (SERM). Tamoxifen has both inhibitory (e.g., mammary cells) and activating (e.g., bone, liver, and uterine cells) activity against estrogens.
Web ID
– T6906
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C26H29NO
Citations
– 1. Li J, Yu F, Guo H, et al. Crystal structure of plant PLDα1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D. Cell Research. 2020, 30(1): 61-69.
2. Li W, Lin J, Shi Z, et al. Clomiphene citrate induces nuclear translocation of the TFEB transcription factor and triggers apoptosis by enhancing lysosomal membrane permeabilization. Biochemical Pharmacology. 2019 Apr;162:191-201
3. Estrogen-induced FXR1 promotes endocrine resistance and bone metastasis in breast cancer via BCL2 and GPX4
References
– Li W, et al. Tamoxifen promotes apoptosis and inhibits invasion in estrogen‑positive breast cancer MCF‑7 cells. Mol Med Rep. 2017 Jul;16(1):478-484.
CAS Number
– 10540-29-1
Molecular Weight
– C26H29NO
Compound Purity
– 0.9992
SMILES
– CCC(C1=CC=CC=C1)=C(/C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1
Pathway
– Apoptosis|||Metabolism|||Autophagy|||Endocrinology/Hormones|||Cytoskeletal Signaling
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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