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TAK-733
$150 – $818
Products Details
Product Description
– TAK-733 is a potent and selective MEK allosteric site inhibitor with an IC50 of 3.2 nM.
Web ID
– HY-13449
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C17H15F2IN4O4
References
– [1]Dong Q, et al. Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1315-9.|[2]Micel LN, et al. Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants. Mol Cancer Ther. 2015 Feb;14(2):317-25.
CAS Number
– 1035555-63-5
Molecular Weight
– 504.23
Compound Purity
– 99.48
SMILES
– O=C1C(C(NC2=CC=C(I)C=C2F)=C(F)C(N3C)=O)=C3N=CN1C[C@@H](O)CO
Clinical Information
– Phase 1
Research Area
– Cancer
Solubility
– DMSO : ≥ 33 mg/mL
Target
– MEK
Isoform
– MEK
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
