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Tacrolimus
Price range: 61 CAD through 410 CAD
Products Details
Product Description
– Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein phosphatase.
Web ID
– T2144
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C44H69NO12
Citations
– 1. Wang W, Ren S, Lu Y, et al. Inhibition of Syk promotes chemical reprogramming of fibroblasts via metabolic rewiring and H2S production. The EMBO Journal. 2021 Jun 1;40(11):e106771. doi: 10.15252/embj.2020106771. Epub 2021 Apr 28.
2. Chang Z, Zhang Q, Hu Q, et al. Tannins in Terminalia bellirica inhibits hepatocellular carcinoma growth via re-educating tumor-associated macrophages and restoring CD8+ T cell function. Biomedicine & Pharmacotherapy. 2022, 154: 113543.
3. Huang, Jing, et al. Osteopontin isoform c promotes the survival of cisplatin-treated NSCLC cells involving NFATc2-mediated suppression on calcium-induced ROS levels.. BMC cancer. 21.1 (2021): 1-14.
References
– Zhu H, et al. Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF‑1α expression in vivo. Mol Med Rep. 2014 Aug;10(2):585-92.
CAS Number
– 104987-11-3
Molecular Weight
– C44H69NO12
Compound Purity
– 0.9898
SMILES
– CO[C@@H]1C[C@@H](CC[C@H]1O)C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@H](C[C@@H](C)CC(C)=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC
Pathway
– Metabolism|||Microbiology/Virology|||Autophagy|||PI3K/Akt/mTOR signaling
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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