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Products Details
Product Description
– SZU-B6, a PROTAC degrader, targets and degrades SIRT6 with DC50 values of 45 nM in SK-HEP-1 cells and 154 nM in Huh-7 cells. It inhibits the proliferation of SK-HEP-1 cells with an IC50 of 1.51 μM and suppresses colony formation in both SK-HEP-1 and Huh-7 cell lines. Additionally, SZU-B6 induces apoptosis in SK-HEP-1 cells and causes cell cycle arrest at the G2/M phase. It demonstrates anti-tumor activity in murine models.
Web ID
– T200927
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C29H32FN7O6
CAS Number
– 3059333-98-8
Molecular Weight
– C29H32FN7O6
SMILES
– O=C1C2=CC(F)=C(C=C2C(=O)N1C3C(=O)NC(=O)CC3)N4CCC(CN5CCN(C6=CC=C(C(N)=C6)N(=O)=O)CC5)CC4
Target
– Others
Pathway
– PROTAC|||Chromatin/Epigenetic|||Apoptosis|||DNA Damage/DNA Repair
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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