Syk Inhibitor II dihydrochloride
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Syk Inhibitor II dihydrochloride

SKU T4391-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 211 CAD through 2,864 CAD

Products Details

Product Description

– Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively).

Web ID

– T4391

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C14H17Cl2F3N6O

References

– Hisamichi H, etal. Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives[J]. Bioorganic & medicinal chemistry, 2005, 13(16): 4936-4951.

CAS Number

– 227449-73-2

Molecular Weight

– C14H17Cl2F3N6O

Compound Purity

– 1

SMILES

– Cl.Cl.NCCNc1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1

Pathway

– Tyrosine Kinase/Adaptors|||Angiogenesis|||Cytoskeletal Signaling|||Chromatin/Epigenetic

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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