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Products Details
Product Description
– SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. SWTX-143 causes irreversible and specific inhibition of the transcriptional activity of YAP/TAZ-TEAD and shows antitumor activity[1].
Web ID
– HY-155338
Shipping
– Room temperature
Molecular Formula
– C19H18F3N3O
References
– [1]Hanne Hillen, et al. A novel irreversible TEAD inhibitor, SWTX-143, blocks Hippo pathway transcriptional output and causes tumor regression in preclinical mesothelioma models. Mol Cancer Ther. 2023 Sep 23.
CAS Number
– 2766575-48-6
Molecular Weight
– 361.36
SMILES
– O=C(C=C)NC1CC2=C(N)C=CC=C2N(C3=CC=C(C(F)(F)F)C=C3)C1
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– YAP
Pathway
– Stem Cell/Wnt
Product type
– Reference compound
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