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Sulfisoxazole
SKU
HY-B0323-100 mg
Category Reference compound
Tags Anti-infection;GPCR/G Protein, Antibiotic;Bacterial;Endothelin Receptor, Cancer; Infection; Endocrinology
$78 – $144
Products Details
Product Description
– Sulfisoxazole (Sulfafurazole) is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A[1][2].
Web ID
– HY-B0323
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C11H13N3O3S
References
– [1]Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34.|[2]Im EJ, et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun. 2019 Mar 27;10(1):1387.
CAS Number
– 127-69-5
Molecular Weight
– 267.30
Compound Purity
– 99.95
SMILES
– O=S(C1=CC=C(N)C=C1)(NC2=C(C)C(C)=NO2)=O
Clinical Information
– Launched
Research Area
– Cancer; Infection; Endocrinology
Solubility
– DMSO : ≥ 150 mg/mL
Target
– Antibiotic;Bacterial;Endothelin Receptor
Isoform
– ETA;ETB
Pathway
– Anti-infection;GPCR/G Protein
Product type
– Reference compound
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