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Sulfasalazine
$55 – $106
Products Details
Product Description
– Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer[1][2][3][4].
Web ID
– HY-14655
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C18H14N4O5S
References
– [1]Mao C, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021;593(7860):586-590.|[2]Wahl C, et al. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J Clin Invest. 1998 Mar 1;101(5):1163-74.|[3]Sykes L, et al. Sulfasalazine augments a pro-inflammatory response in interleukin-1β-stimulated amniocytes and myocytes. Immunology. 2015 Dec;146(4):630-44.|[4]Chung WJ, et al. Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-kappaB. J Neurochem. 2009 Jul;110(1):182-93.
CAS Number
– 599-79-1
Molecular Weight
– 398.39
Compound Purity
– 99.10
SMILES
– OC(C1=C(O)C=CC(/N=N/C2=CC=C(S(=O)(NC3=NC=CC=C3)=O)C=C2)=C1)=O
Clinical Information
– Launched
Research Area
– Cancer; Infection; Inflammation/Immunology
Solubility
– DMSO : 80 mg/mL (ultrasonic;warming)|NH4OH : 150 mg/mL (ultrasonic;adjust pH to 9 with NH4OH)
Target
– Antibiotic;Apoptosis;Autophagy;Bacterial;Ferroptosis;NF-κB
Isoform
– RelA/p65
Pathway
– Anti-infection;Apoptosis;Autophagy;NF-κB
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
