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Sulfasalazine
Price range: 48 CAD through 211 CAD
Products Details
Product Description
– Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative with affinity for elastin-containing connective tissues and formulated as a prodrug. Sulfasalazine induces iron death and inhibits NF-κB, TGF-β and COX-2.
Web ID
– T0907
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C18H14N4O5S
Citations
– 1. Ma R, Fang L, Chen L, et al. Ferroptotic stress promotes macrophages against intracellular bacteria. Theranostics. 2022, 12(5): 2266
2. Lu Y, Yang Q, Su Y, et al. MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma. Cell Death & Disease. 2021, 12(6): 1-14.
3. Ni H, Ruan G, Sun C, et al. Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis. Environmental Toxicology. 2021
4. Wang Y, Wang S, Xin Y, et al. Hydrogen sulfide alleviates the anxiety-like and depressive-like behaviors of type 1 diabetic mice via inhibiting inflammation and ferroptosis. Life Sciences. 2021: 119551.
5. Cao Y, Wang Y, Li Y, et al.Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability.Journal of Natural Medicines.2024: 1-13.
6. Hu C, Chen Y, Jin T, et al.A derivative of tanshinone IIA and salviadione, 15a, inhibits inflammation and alleviates DSS-induced colitis in mice by direct binding and inhibition of RIPK2.Acta Pharmacologica Sinica.2024: 1-15.
References
– Gadangi P, et al. J Immunol,1996, 156(5), 1937-1941.
CAS Number
– 599-79-1
Molecular Weight
– C18H14N4O5S
Compound Purity
– 0.9887
SMILES
– OC(=O)C1=CC(=CC=C1O)N=NC1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC=N1
Target
– Others
Pathway
– Microbiology/Virology|||Immunology/Inflammation|||NF-κB|||Neuroscience|||Apoptosis|||Autophagy
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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