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(S,R,S)-AHPC-phenol-C4-NH2 (dihydrochloride)
SKU
HY-136184-10 mg
Category Reference compound
Tags Cancer, E3 Ligase Ligand-Linker Conjugates, PROTAC
$120 – $1,040
Products Details
Product Description
– (S,R,S)-AHPC-phenol-C4-NH2 (VH032-phenol-C4-NH2) dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology[1].
Web ID
– HY-136184
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H43Cl2N5O5S
References
– [1][3].Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.|[2]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.
CAS Number
– 2376990-26-8
Molecular Weight
– 632.64
Compound Purity
– 99.01
SMILES
– [H]Cl.[H]Cl.CC(N[C@H](C(N1C[C@@H](C[C@H]1C(NCC2=CC=C(C=C2OCCCCN)C3=C(N=CS3)C)=O)O)=O)C(C)(C)C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– E3 Ligase Ligand-Linker Conjugates
Pathway
– PROTAC
Product type
– Reference compound
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