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(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2

SKU HY-131387-100 mg Category Reference compound Tags Cancer, E3 Ligase Ligand-Linker Conjugates, PROTAC

$550 – $1,250

Size100 mg

25 mg 100 mg

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$1,250

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Products Details

Product Description

– (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 can be used in PROTAC BRD4 Degrader-5 (HY-133737) and PROTAC BRD4 Degrader-5-CO-PEG3-N3 (HY-133736)[1].

Web ID

– HY-131387

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C31H47N5O7S

References

– [1]Marı A Maneiro, et al. Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS Chem Biol. 2020 Jun 19;15(6):1306-1312.

CAS Number

– 2409538-69-6

Molecular Weight

– 633.80

Compound Purity

– 96.12

SMILES

– NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)

Target

– E3 Ligase Ligand-Linker Conjugates

Isoform

– von Hippel-Lindau (VHL)

Pathway

– PROTAC

Product type

– Reference compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.