Sodium dichloroacetate
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Sodium dichloroacetate

SKU T3604-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 50 CAD through 213 CAD

Products Details

Product Description

– Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth.

Web ID

– T3604

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C2HCl2NaO2

Citations

– 1. Qiu X, Jiang Z, Luo Y, et al.PPP3CB Inhibits Cell Proliferation and the Warburg Effect in Bladder Cancer by Blocking PDHK1.Frontiers in Bioscience-Landmark.2024, 29(2): 48.

References

– Bonnet S, et al. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell. 2007 Jan;11(1):37-51.

CAS Number

– 2156-56-1

Molecular Weight

– C2HCl2NaO2

Compound Purity

– 0.9932

SMILES

– C(C(=O)[O-])(Cl)Cl.[Na+]

Pathway

– PI3K/Akt/mTOR signaling|||Apoptosis|||Immunology/Inflammation|||NF-κB|||Metabolism

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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