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Products Details
Product Description
– SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effectively degrades the ERα protein with an IC50 value of 0.097 μM. Within cells, SNIPER(ER)-87 selectively recruits XIAP to ERα, and XIAP functions as the primary E3 ubiquitin ligase responsible for the degradation of ERα induced by SNIPER(ER)-87[1][2].
Web ID
– T18697
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C59H73N5O10S
References
– Ohoka N, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017 Mar 17;292(11):4556-4570.
CAS Number
– 2222354-91-6
Molecular Weight
– C59H73N5O10S
SMILES
– [H][C@]1(CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1)c1nc(cs1)C(=O)c1cccc(OCCOCCOCCOCC(=O)N(C)CCOc2ccc(cc2)C(=C(CC)c2ccccc2)c2ccc(O)cc2)c1 |w:58.61|
Target
– Others
Pathway
– Others
Product type
– PROTAC
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