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Simvastatin
Price range: 58 CAD through 456 CAD
Products Details
Product Description
– Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovascular disease.
Web ID
– T0687
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C25H38O5
Citations
– 1. Zhang W, Pan X, Xu Y, et al.Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA.Acta Pharmaceutica Sinica B.2023
2. Wang D, Wang Y, Di X, et al.Cortical tension drug screen links mitotic spindle integrity to Rho pathway.Current Biology.2023
3. Zhang L, Yi Y, Wang T, et al.25-Hydroxycholesterol inhibits classical swine fever virus entry into porcine alveolar macrophages by depleting plasma membrane cholesterol.Veterinary Microbiology.2023: 109668.
4. Wei Y H, Liao S L, Wang S H, et al. Simvastatin and ROCK Inhibitor Y-27632 Inhibit Myofibroblast Differentiation of Graves’ Ophthalmopathy-Derived Orbital Fibroblasts via RhoA-Mediated ERK and p38 Signaling Pathways. Frontiers in Endocrinology. 2021 Feb 1;11:607968. doi: 10.3389/fendo.2020.607968. eCollection 2020.
5. Wei Y H, Liao S L, Wang C C, et al. Simvastatin Inhibits CYR61 Expression in Orbital Fibroblasts in Graves’ Ophthalmopathy through the Regulation of FoxO3a Signaling. Mediators of Inflammation. 2021 Jan 20;2021:8888913. doi: 10.1155/2021/8888913. eCollection 2021.
6. Tang Y, Fang G, Guo F, et al. Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer. Cancer Cell. 2020, 38(1): 115-128. e9.
7. Khalifa B A, Guijarro A, Ravera S, et al.Cyclic fasting bolsters cholesterol biosynthesis inhibitors’ anticancer activity.Nature Communications.2023, 14(1): 6951.
8. Noè R, Inglese N, Romani P, et al.Organic Selenium induces ferroptosis in pancreatic cancer cells.Redox Biology.2023: 102962.
9. Tan X D, Luo C F, Liang S Y.Antihyperlipidemic drug rosuvastatin suppressed tumor progression and potentiated chemosensitivity by downregulating CCNA2 in lung adenocarcinoma.Journal of Chemotherapy.2024: 1-13.
10. Dang Y, Wang Y, Wei J, et al.25-Hydroxycholesterol inhibits Hantavirus infection by reprogramming cholesterol metabolism.Free Radical Biology and Medicine.2024
References
– Wang G, et al. Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway. Sci Rep. 2016 Oct 25;6:35783.
CAS Number
– 79902-63-9
Molecular Weight
– C25H38O5
Compound Purity
– 0.9995
SMILES
– CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12
Target
– Ras
Pathway
– Metabolism|||Apoptosis|||Autophagy
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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