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Sildenafil (citrate)
$55 – $264
Products Details
Product Description
– Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM.
Web ID
– HY-15025A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C28H38N6O11S
Citations
– Sci Rep. 2020 Oct 2;10(1):16383.|ACS Omega. 2020 Nov 15;5(46):29935-29942.|Biochem Biophys Res Commun. 2021 Feb 12;547:9-14.|Bioeng Transl Med. 2023 Jul 2.|Int J Mol Sci. 2022 Jun 20;23(12):6860.|Physiol Rep. 2023 Jan;11(1):e15549.
References
– [1]Moretti R, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 28;13(1):95.|[2]Korkmaz MF, et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar;33(2):204-11.|[3]Li BB, et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl). 2011 Sep;124(17):2733-40.|[4]Wang Z, et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov;10(11):2790-7.
CAS Number
– 171599-83-0
Molecular Weight
– 666.70
Compound Purity
– 99.73
SMILES
– O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(C)CC4)=O)=CC=C3OCC)N1.O=C(CC(C(O)=O)(O)CC(O)=O)O
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)|H2O : 2 mg/mL (ultrasonic)
Target
– Apoptosis;Autophagy;Bacterial;Phosphodiesterase (PDE)
Isoform
– PDE5
Pathway
– Anti-infection;Apoptosis;Autophagy;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
