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Products Details
Product Description
– SIAIS164018, a PROTAC-based ALK and EGFR degrader derived from Brigatinib, exhibits IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R. It significantly hampers cancer cell migration and invasion, induces G1 cell cycle arrest, and triggers apoptosis, demonstrating superior properties compared to Brigatinib [1].
Web ID
– T74570
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C43H48ClN10O7P
CAS Number
– 2353492-68-7
Molecular Weight
– C43H48ClN10O7P
SMILES
– COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCC(CC1)N1CCN(CC1)C(=O)CNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
Pathway
– Others
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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