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Products Details
Product Description
– SIAIS117, a potent Brigatinib-PROTAC degrader, effectively degrades the ALK G1202R point mutation through its design based on Brigatinib and VHL-1 conjunction. It inhibits the proliferation of SR and H2228 cancer cell lines, demonstrating potential anti-proliferative effects against small cell lung cancer [1].
Web ID
– T74489
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C57H76ClN10O7PS
CAS Number
– 2353494-84-3
Molecular Weight
– C57H76ClN10O7PS
SMILES
– COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCC(CC1)NC(=O)CCCCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C
Pathway
– Others
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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