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(+)-Shikonin
Price range: 46 CAD through 899 CAD
Products Details
Product Description
– (+)-Shikonin(Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor.(+)- Shikonin exhibits antitumor, anti-inflammatory and wound healing activities.
Web ID
– T1125
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C16H16O5
Citations
– 1. Lu J, Liu S Y, Zhang J, et al. Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma. American Journal of Cancer Research. 2021, 11(7): 3575.
2. Sha X, Lin J, Wu K, et al.The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease.Cell Death & Disease.2025, 16(1): 14.
References
– Zhang FY, et al. Shikonin Inhibits the Migration and Invasion of Human Glioblastoma Cells by Targeting Phosphorylated β-Catenin and Phosphorylated PI3K/Akt: A Potential Mechanism for the Anti-Glioma Efficacy of a Traditional Chinese Herbal Medicine. Int J Mol Sci. 2015 Oct 9;16(10):23823-48.
CAS Number
– 517-89-5
Molecular Weight
– C16H16O5
Compound Purity
– 0.9854
SMILES
– CC(C)=CC[C@@H](O)C1=CC(=O)c2c(O)ccc(O)c2C1=O
Target
– Retinoid Receptor
Pathway
– Metabolism|||Apoptosis|||Microbiology/Virology|||Membrane transporter/Ion channel|||NF-κB|||Proteases/Proteasome
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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