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Products Details
Product Description
– SD-436 is a highly selective and efficient STAT3 PROTAC degrader, with a DC50 of 0.5 μM. It exhibits IC50 values of 19 nM for STAT3, 270 nM for STAT1, 360 nM for STAT4, and >10 μM for both STAT5 and STAT6. SD-436 promotes the ubiquitination and degradation of STAT3, and it induces tumor regression. This compound is applicable for tumor research, including studies on leukemia and lymphoma.
Web ID
– T203395
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C58H62F4N9O14PS
CAS Number
– 2497585-50-7
Molecular Weight
– C58H62F4N9O14PS
SMILES
– C(#CCCC1CCN(C([C@H](CC2=CC(F)=C(F)C=C2)NC([C@@H](NC(=O)[C@H]3N4[C@](CC3)(CCN(C(OC)=O)C[C@H](NC(=O)C5=CC=6C(S5)=CC=C(C(P(=O)(O)O)(F)F)C6)C4=O)[H])CCC(N)=O)=O)=O)CC1)C7=C8C(C(=O)N(C8)C9C(=O)NC(=O)CC9)=CC=C7
Target
– PROTACs
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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