SC79

SKU T2274-5 mg Category Brand:

Price range: 83 CAD through 845 CAD

Products Details

Product Description

– SC79 is an AKT agonist with specificity and blood-brain barrier permeability. SC79 specifically binds to the PH domain of AKT, activates cytoplasmic AKT, and inhibits AKT membrane translocation. SC79 has neuroprotective activity.

Web ID

– T2274

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C17H17ClN2O5

Citations

– 1. Chen H, He A, Li H, et al. TSSK4 upregulation in alveolar epithelial type-II cells facilitates pulmonary fibrosis through HSP90-AKT signaling restriction and AT-II apoptosis. Cell Death & Disease. 2021, 12(10): 1-1 2. Liu Y, Lv H, Li X, et al. Cyclovirobuxine inhibits the progression of clear cell renal cell carcinoma by suppressing the IGFBP3-AKT/STAT3/MAPK-Snail signalling pathway. International Journal of Biological Sciences. 2021, 17(13): 3522-3537. 3. Zhang H, Xia P, Liu J, et al. ATIC inhibits autophagy in hepatocellular cancer through the AKT/FOXO3 pathway and serves as a prognostic signature for modeling patient survival. International Journal of Biological Sciences. 2021, 17(15): 4442-4458. 4. Xu Y, Jiang E, Shao Z, et al. LncRNA FENDRR in Carcinoma-Associated Fibroblasts Regulates the Angiogenesis of Oral Squamous Cell Carcinoma Through the PI3K/AKT Pathway. Frontiers in Oncology. 2021, 11. 5. Wang X, Zhu P, Xu S, et al. Antimony, a novel nerve poison, triggers neuronal autophagic death via reactive oxygen species-mediated inhibition of the protein kinase B/mammalian target of rapamycin pathway. The International Journal of Biochemistry & Cell Biology. 2019, 114: 105561 6. Shi W, Tang Y, Zhi Y, et al Akt inhibition-dependent downregulation of the Wnt/β-Catenin Signaling pathway contributes to antimony-induced neurotoxicity. Science of the Total Environment. 2020, 737: 140252 7. Chen C, Zhang H, Hou S, et al. Shenxian-Shengmai Oral Liquid Evoke Autophagy of Fibroblast to Attenuate Sinoatrial Node Fibrosis in Sick Sinus Syndrome Mice via the AKT/mTOR Pathway. Evidence-Based Complementary and Alternative Medicine. 2022 8. Wang J, Yu Z, Jiang Y, et al.Downregulation of MTHFD2 Inhibits Proliferation and Enhances Chemosensitivity in Hepatocellular Carcinoma via PI3K/AKT Pathway.Frontiers in Bioscience-Landmark.2024, 29(1): 35. 9. Liu Y, Hou Y, Zhang F, et al.ENO1 deletion potentiates ferroptosis and decreases glycolysis in colorectal cancer cells via AKT/STAT3 signaling.Experimental and Therapeutic Medicine.2024, 27(4): 1-9. 10. Yang H, Wu B, Yang Q, et al.Urolithin C suppresses colorectal cancer progression via the AKT/mTOR pathway.Journal of Natural Medicines.2024: 1-14.

References

– Jo H, et al. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10581-6.

CAS Number

– 305834-79-1

Molecular Weight

– C17H17ClN2O5

Compound Purity

– 0.9993

SMILES

– CCOC(=O)C(C#N)C1C(C(=O)OCC)=C(N)Oc2ccc(Cl)cc12

Pathway

– PI3K/Akt/mTOR signaling|||Cytoskeletal Signaling

Product type

– Small Compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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