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SB-431542
Price range: 80 CAD through 877 CAD
Products Details
Product Description
– SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective. SB 431542 also has inhibitory activity against ALK4 and ALK7 but not other proteins. SB 431542 can be used for induced differentiation of stem cells.
Web ID
– T1726
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C22H16N4O3
Citations
– 1. Chen X, Wang P, Qiu H, et al. Integrative epigenomic and transcriptomic analysis reveals the requirement of JUNB for hematopoietic fate induction. Nature Communications. 2022, 13(1): 1-16
2. Duan F, Huang R, Zhang F, et al. Biphasic modulation of insulin signaling enables highly efficient hematopoietic differentiation from human pluripotent stem cells. Stem Cell Research & Therapy. 2018 Jul 27;9(1):205
3. Bao, Shixiang, et al. TGF-β1 Induces Immune Escape by Enhancing PD-1 and CTLA-4 Expression on T Lymphocytes in Hepatocellular Carcinoma. Frontiers in Oncology. 11 (2021): 2516.
4. Bao, Shixiang, et al. TGF-β1 Induces Immune Escape by Enhancing PD-1 and CTLA-4 Expression on T Lymphocytes in Hepatocellular Carcinoma. Frontiers in Oncology. 11 (2021): 2516.
5. Bao, Shixiang, et al. TGF-β1 Induces Immune Escape by Enhancing PD-1 and CTLA-4 Expression on T Lymphocytes in Hepatocellular Carcinoma. Frontiers in Oncology. 11 (2021): 2516.
6. Fu J, Jiang L, Yu B, et al. Generation of a Human iPSC Line CIBi010-A with a Reporter for ASGR1 Using CRISPR/Cas9. Stem Cell Research. 2022: 102800
7. Liu S, Yan X, Guo J, et al.Periodontal ligament‐associated protein‐1 knockout mice regulate the differentiation of osteoclasts and osteoblasts through TGF‐β1/Smad signaling pathway.Journal of Cellular Physiology.2023
8. Ying J, Wang P, Jin X, et al.TGF-β1 Mediates the EndoMt in High Glucose-Treated Human Retinal Microvascular Endothelial Cells.Seminars in Ophthalmology. Taylor & Francis.2024: 1-8.
9. Yang Y, Suo N, Cui S, et al.Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation.Acta Pharmacologica Sinica.2024: 1-13.
10. Liu B, Li C, Bo Y, et al.Let‑7f‑5p Regulated by Hsa_circ_0000437 Ameliorates Bleomycin‐Induced Skin Fibrosis.Journal of Cellular Biochemistry.e30629.
References
– Halder SK, et al. A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia. 2005 May;7(5):509-21.
CAS Number
– 301836-41-9
Molecular Weight
– C22H16N4O3
Compound Purity
– 0.9959
SMILES
– NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccccn1)-c1ccc2OCOc2c1
Target
– Endogenous Metabolite
Pathway
– Angiogenesis|||Stem Cells|||Tyrosine Kinase/Adaptors
Product type
– Small Compound
New Class
– Top-SmallMol
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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