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Products Details
Product Description
– (S)-Sitagliptin phosphate is the less active S-enantiomer of Sitagliptin phosphate. Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts[1].
Web ID
– HY-13749C
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C16H18F6N5O5P
References
– [1]Chi-Hung Ho, et al. Biocatalytic Continuous Manufacturing of Diabetes Drug: Plantwide Process Modeling, Optimization, and Environmental and Economic Analysis. ACS Sustainable Chem. Eng. 2019, 7, 1, 1038-1051.
CAS Number
– 823817-58-9
Molecular Weight
– 505.31
SMILES
– O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@@H](N)CC3=CC(F)=C(F)C=C3F.O=P(O)(O)O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Autophagy;Dipeptidyl Peptidase
Isoform
– DPP-4
Pathway
– Autophagy;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
