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Products Details
Product Description
– Ryuvidine is a potent inhibitor of SET domain-containing protein 8(SETD8) with an IC50 of 0.5 µM and suppresses monomethylation of H4K20 in vitro[1]. Ryuvidine also inhibits CDK4 with an IC50 of 6.0 μM and is cytotoxic against a range of human cancer cells[2].
Web ID
– HY-100624
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C15H12N2O2S
References
– [1]Ryu CK, et al. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorg Med Chem Lett. 2000 Mar 6;10(5):461-4. |[2]Blum G, et al. Small-molecule inhibitors of SETD8 with cellular activity. ACS Chem Biol. 2014 Nov 21;9(11):2471-8.
CAS Number
– 265312-55-8
Molecular Weight
– 284.33
SMILES
– O=C1C=C(C(C2=C1SC(C)=N2)=O)NC3=CC=C(C)C=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– CDK
Isoform
– CDK4
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
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