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Ruxolitinib phosphate
Price range: 70 CAD through 1,037 CAD
Products Details
Product Description
– Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Its selectivity for JAK1/2 is more than 130 times that of JAK3.
Web ID
– T3043
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C17H21N6O4P
Citations
– 1. Zhang M, Yang W, Wang P, et al. CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer. Nature communications. 2020, 11(1): 1-17
2. Gao C, Yan Y, Chen G, et al. Autophagy Activation Represses Pyroptosis through the IL-13 and JAK1/STAT1 Pathways in a Mouse Model of Moderate Traumatic Brain Injury. ACS Chemical Neuroscience. 2020
3. Yang M, Bai M, Zhuang Y, et al.High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury.Neural Regeneration Research.2025: 10.4103.
References
– Quintas-Cardama A, et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood, 2010, 115(15), 3109-3117.
CAS Number
– 1092939-17-7
Molecular Weight
– C17H21N6O4P
Compound Purity
– 0.9991
SMILES
– OP(O)(O)=O.N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Pathway
– Angiogenesis|||JAK/STAT signaling|||Stem Cells|||Chromatin/Epigenetic|||Autophagy|||Tyrosine Kinase/Adaptors
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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