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Rotundine
$66 – $73
Products Details
Product Description
– Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC50s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of 5-HT1A with an IC50 of 370 nM.
Web ID
– HY-N0096
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C21H25NO4
References
– [1]Wang JB, et al. l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction. Future Med Chem. 2012 Feb;4(2):177-86.|[2]Liu YL, et al. Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice. Acta Pharmacol Sin. 2005 May;26(5):533-8.
CAS Number
– 483-14-7
Molecular Weight
– 355.43
Compound Purity
– 99.87
SMILES
– COC1=CC=C2C(CN3CCC4=CC(OC)=C(OC)C=C4[C@]3([H])C2)=C1OC
Clinical Information
– Launched
Research Area
– Neurological Disease
Solubility
– DMSO : ≥ 100 mg/mL|H2O : 0.67 mg/mL (ultrasonic)
Target
– 5-HT Receptor;Dopamine Receptor
Isoform
– 5-HT1 Receptor;D1 Receptor;D2 Receptor;D3 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
