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Product Description
– Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM[1][2].
Web ID
– HY-D0143A
Shipping
– Room temperature
Molecular Formula
– C20H26Cl2N2O2
References
– [1]Shilu Malakar，et al. Drug repurposing of quinine as antiviral against dengue virus infection. Virus Res. 2018 Aug 15;255:171-178. doi: 10.1016/j.virusres.2018.07.018. Epub 2018 Jul 25.|[2]Jhanwar, Deepika，et al. Chemoprevention of DMBA induced skin carcinogenesis in swiss albino mice by quinine sulfate.(2016): 2636-2640.|[3]Ebenezer O Farombi, et al. Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulfate in rats. J Basic Clin Physiol Pharmacol. 2012 Feb 27;23(1):39-44.
CAS Number
– 60-93-5
Molecular Weight
– 397.34
SMILES
– C=C[C@H](C[N@@]1CC2)[C@H]2C[C@@H]1[C@H](O)C3=CC=NC4=CC=C(OC)C=C34.Cl.Cl
Clinical Information
– Launched
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Flavivirus;Parasite;Potassium Channel
Isoform
– Plasmodium
Pathway
– Anti-infection;Membrane Transporter/Ion Channel
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
