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Probenecid
$55 – $106
Products Details
Product Description
– Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels.
Web ID
– HY-B0545
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C13H19NO4S
References
– [1]Bakos E, et al. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57(4):760-8.|[2]Koch SE, et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012 Jul;53(1):134-44.|[3]Greene TA, et al. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One. 2011;6(5):e20123.|[4]Silverman W, et al. Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol. 2008 Sep;295(3):C761-7.
CAS Number
– 57-66-9
Molecular Weight
– 285.36
Compound Purity
– 99.95
SMILES
– O=C(O)C1=CC=C(S(=O)(N(CCC)CCC)=O)C=C1
Clinical Information
– Launched
Research Area
– Metabolic Disease; Cancer
Solubility
– 0.5 M NaOH : 100 mg/mL (ultrasonic;adjust pH to 12 with NaOH)|DMSO : ≥ 100 mg/mL
Target
– Bacterial;HIV;TRP Channel
Pathway
– Anti-infection;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
