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Pomalidomide-PEG1-NH2 (hydrochloride)
SKU
HY-136772-10 mg
Category Reference compound
Tags E3 Ligase Ligand-Linker Conjugates, Others, PROTAC
$210 – $1,800
Products Details
Product Description
– Pomalidomide-PEG1-NH2 hydrochloride is a crosslinker-E3 ligase ligand conjugate, consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand[1].
Web ID
– HY-136772
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C17H19ClN4O6
References
– [1]Lee B, et al. Synthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug. J Enzyme Inhib Med Chem. 2023 Dec;38(1):51-66.
CAS Number
– 2380273-67-4
Molecular Weight
– 410.81
Compound Purity
– 97.05
SMILES
– [H]Cl.NCCOCC(NC1=CC=CC(C2=O)=C1C(N2C(C3=O)CCC(N3)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– DMSO : 62.5 mg/mL (ultrasonic)
Target
– E3 Ligase Ligand-Linker Conjugates
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.