Pirfenidone
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Pirfenidone

SKU T2386-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 48 CAD through 347 CAD

Products Details

Product Description

– Pirfenidone (AMR69) inhibits the production of CCL2 and CCL12 in fibroblasts and also decreases TGF-β2 protein levels. Pirfenidone is an antifibrotic agent that is commonly used in studies related to pulmonary fibrosis and also has anti-inflammatory activity.

Web ID

– T2386

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C12H11NO

Citations

– 1. Hong M J, Hao M J, Zhang G Y, et al. Exophilone, a Tetrahydrocarbazol-1-one Analogue with Anti-Pulmonary Fibrosis Activity from the Deep-Sea Fungus Exophiala oligosperma MCCC 3A01264. Marine Drugs. 2022, 20(7): 448 2. Liang H X, Hao M J, Zhang G Y, et al.Lentinuses A–B, two alkaloids from the marine-derived fungus Lentinus sajor-caju with potent anti-pulmonary fibrosis activity.Fitoterapia.2023: 105433. 3. Tian J, Song D, Peng Y, et al.Silica-induced macrophage pyroptosis propels pulmonary fibrosis through coordinated activation of relaxin and osteoclast differentiation signaling to reprogram fibroblasts.Ecotoxicology and Environmental Safety.2024, 273: 116106. 4. Chen Z, Yun X, Tian J, et al.Engineering Macrophage‐Derived Exosome to Deliver Pirfenidone: A Novel Approach to Combat Silicotic Pulmonary Fibrosis.Advanced Healthcare Materials.2403227 5. Wang Q, Liu X, Yuan H, et al.Inhalable Carbonyl Sulfide Donor-Hybridized Selective Phosphodiesterase 10A Inhibitor for Treating Idiopathic Pulmonary Fibrosis by Inhibiting Tumor Growth Factor-β Signaling and Activating the cAMP/Protein Kinase A/cAMP Response Element-Binding Protein (CREB)/p53 Axis.ACS Pharmacology & Translational Science.2024

References

– Nakazato H, et al. Eur J Pharmacol, 2002, 446(1-3), 177-185.

CAS Number

– 53179-13-8

Molecular Weight

– C12H11NO

Compound Purity

– 0.9979

SMILES

– O=C1N(C=C(C)C=C1)C2=CC=CC=C2

Pathway

– Stem Cells|||Immunology/Inflammation|||GPCR/G Protein|||Microbiology/Virology

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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