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Products Details
Product Description
– Pimethixene is antihistamine and antiserotonergic compound, acts as an antimigraine agent.
Pimethixene is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively[1].
Web ID
– HY-B1101
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C19H19NS
References
– [1]Schmitz B, et al. BF-1–a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15;751:73-80.
CAS Number
– 314-03-4
Molecular Weight
– 293.43
SMILES
– CN1CC/C(CC1)=C2C3=C(SC4=C2C=CC=C4)C=CC=C3
Clinical Information
– Launched
Research Area
– Neurological Disease; Endocrinology
Solubility
– 10 mM in DMSO
Target
– 5-HT Receptor;Histamine Receptor
Isoform
– 5-HT1 Receptor;5-HT2 Receptor;H1 Receptor
Pathway
– GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Product type
– Reference compound
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