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Products Details
Product Description
– Pimethixene is antihistamine and antiserotonergic compound, acts as an antimigraine agent.
Pimethixene is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively[1].
Web ID
– HY-B1101
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C19H19NS
References
– [1]Schmitz B, et al. BF-1–a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15;751:73-80.
CAS Number
– 314-03-4
Molecular Weight
– 293.43
SMILES
– CN1CC/C(CC1)=C2C3=C(SC4=C2C=CC=C4)C=CC=C3
Clinical Information
– Launched
Research Area
– Neurological Disease; Endocrinology
Solubility
– 10 mM in DMSO
Target
– 5-HT Receptor;Histamine Receptor
Isoform
– 5-HT1 Receptor;5-HT2 Receptor;H1 Receptor
Pathway
– GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
