Download Files:
Pim1/AKK1-IN-1
Price range: 131 CAD through 1,680 CAD
Products Details
Product Description
– Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.
Web ID
– T5093
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C20H13N5O
Citations
– 1. Wang T, Guo H, Li Q, et al. The AMPK-HOXB9-KRAS axis regulates lung adeno carcinoma growth in response to cellular energy al terations. Cell Reports. 2022, 40(8): 111210
2. Yang W, Sun X, Liu S, et al.TLR8 agonist Motolimod-induced inflammatory death for treatment of acute myeloid leukemia.Biomedicine & Pharmacotherapy.2023, 163: 114759.
3. Qin W, Ding Y, Zhang W, et al.Small molecule-driven LKB1 deacetylation is responsible for the inhibition of hepatic lipid response in NAFLD.Journal of Lipid Research.2025: 100740.
References
– Bamborough P, et al. Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. J Med Chem. 2008 Dec 25;51(24):7898-914.
CAS Number
– 1093222-27-5
Molecular Weight
– C20H13N5O
Compound Purity
– 0.9784
SMILES
– O=C(Nc1c[nH]c2ncc(cc12)-c1ccc(cc1)C#N)c1cccnc1
Pathway
– Chromatin/Epigenetic|||JAK/STAT signaling|||Stem Cells
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
