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Pilocarpine (Hydrochloride)
$42 – $106
Products Details
Product Description
– Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
Web ID
– HY-B0726
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C11H17ClN2O2
Citations
– Brain Res. 2023 Apr 29;148382.|Brain Sci. 2023, 13(2), 262.|Cell Mol Neurobiol. 2020 Oct 15. |Epilepsy Res. 2018 May;142:45-52. |Food Chem. 30 November 2022, 133593.|Immunity. 2022 Jul 12;S1074-7613(22)00291-6.|Int Immunopharmacol. 2022 Aug 22;111:109152.|J Mol Neurosci. 2020 Nov;70(11):1858-1870.|Neuropharmacology. 2017 May 1;117:238-248.|Neuroscience. 2021 Feb 10;455:212-222.|Research Square Preprint. 2021 Aug.|Cell Rep. 2023 Apr 30;42(5):112456.|Int J Mol Sci. 2023 Apr 12;24(8):7171.|Int J Mol Sci. 2023 Apr 16, 24(8), 7356.|Life Sci. 2022 Nov 1;308:120942.|Prog Neurobiol. 2022 Aug 2;102335.|Research Square Preprint. 2023 Apr 13.|Research Square Print. December 16th, 2022.
References
– [1]Tonta MA, et al. Pilocarpine-induced relaxation of rat tail artery by a non-cholinergic mechanism and in the absence of an intact endothelium. Br J Pharmacol. 1994 Jun;112(2):525-32.|[2]Wang RF, et al. Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus. Epilepsy Res. 2018 Mar 9;142:45-52.|[3]Matsuzaki K, et al. Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands. FEBS Open Bio. 2017 Dec 7;8(1):85-93.|[4]Yuan XL, et al. Cytotoxicity of pilocarpine to human corneal stromal cells and its underlying cytotoxic mechanisms. Int J Ophthalmol. 2016 Apr 18;9(4):505-11.
CAS Number
– 54-71-7
Molecular Weight
– 244.72
Compound Purity
– 99.98
SMILES
– CN1C(C[C@@H](COC2=O)[C@@H]2CC)=CN=C1.Cl
Clinical Information
– Launched
Research Area
– Neurological Disease; Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 37 mg/mL
Target
– mAChR
Isoform
– mAChR3
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
