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Physostigmine (hemisulfate)
$150 – $260
Products Details
Product Description
– Physostigmine hemisulfate (Eserine hemisulfate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine hemisulfate can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine hemisulfate can reverse memory deficits in transgenic mice with Alzheimer’s disease. Physostigmine hemisulfate is also an antidote for anticholinergic poisoning[1][2][3][4].
Web ID
– HY-N2320
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C15H21N3O2.1/2H2O4S
References
– [1]Jonathan D Kenny, et al. Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats. Anesth Analg. 2016 Nov;123(5):1210-1219.|[2]Haase U, et al. Pharmakotherapie–physostigmin post OP [Pharmacotherapy–physostigmine administered post-operatively]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2007;42(3):188‐189.|[3]Dong H, et al, Bertchume A, Vallera D, Csernansky JG. Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer’s disease. Psychopharmacology (Berl). 2005;181(1):145‐152.|[4]Frascogna N. Physostigmine: is there a role for this antidote in pediatric poisonings? Curr Opin Pediatr. 2007;19(2):201‐205.
CAS Number
– 64-47-1
Molecular Weight
– 324.38
Compound Purity
– 98.0
SMILES
– CN1[C@](N(C)CC2)([H])[C@]2(C)C3=C1C=CC(OC(NC)=O)=C3.O=S(O)(O)=O.[1/2]
Clinical Information
– Phase 4
Research Area
– Neurological Disease
Solubility
– H2O : 50 mg/mL (ultrasonic)
Target
– Cholinesterase (ChE)
Isoform
– AChE
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
