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Perzinfotel
SKU
HY-19168-10 mg
Category Reference compound
Tags iGluR, Membrane Transporter/Ion Channel;Neuronal Signaling, Neurological Disease
$210 – $1,850
Products Details
Product Description
– Perzinfotel (EAA-090) is a potent, selective, and competitive NMDA receptor antagonist with neuroprotective effects. Perzinfotel (EAA-090) shows high affinity (IC50=30 nM) for the glutamate site[1][2].
Web ID
– HY-19168
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C9H13N2O5P
References
– [1]Brandt MR, et al. Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid] on chemically induced thermal hypersensitivity. J Pharmacol Exp Ther. 2005 Jun;313(3):1379-86.|[2]Kinney WA, et al. Design and synthesis of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid(EAA-090), a potent N-methyl-D-aspartate antagonist, via the use of 3-cyclobutene-1,2-dione as an achiral alpha-amino acid bioisostere. J Med Chem. 1998 Jan 15;41(2):236-46.
CAS Number
– 144912-63-0
Molecular Weight
– 260.18
Compound Purity
– 99.43
SMILES
– O=C(C1=C2NCCCN1CCP(O)(O)=O)C2=O
Clinical Information
– Phase 2
Research Area
– Neurological Disease
Solubility
– DMSO : 20.83 mg/mL (ultrasonic)|H2O : 5.88 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– iGluR
Isoform
– NMDA Receptor
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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