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Pemetrexed (disodium)
$66 – $158
Products Details
Product Description
– Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[1].
Web ID
– HY-10820A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H19N5Na2O6
Citations
– Beilstein J Org Chem. 2017 Oct 25;13:2252-2263.|Clin Transl Oncol. 2022 Jul 19.|Faculty of the Graduate School of Biomedical Sciences. The University of Texas Southwestern Medical Center. Oct 1. 2015.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Mol Cell. 2019 Dec 5;76(5):838-851.e5.|Odontology. 2020 Apr;108(2):300-311.|Acta Pharmacol Sin. 2021 Jan;42(1):108-114.|Br J Cancer. 2023 Jun 27.|Cell Death Discov. 2022 Jul 5;8(1):307.|Cell Rep Med. 2023 Jan 10;100911.|Commun Biol. 2022 Jun 23;5(1):619.|Int Immunopharmacol. 2023 Nov 3;125(Pt A):111158.|J Clin Invest. 2021 Aug 2;131(15):e138022.|J Control Release. 2022 Dec 9;353:490-506.|Pharmacol Res Perspect. 2020 Apr;8(2):e00575.|Research Square Print. September 27th, 2022.|Theranostics. 2020 May 15;10(13):6048-6060.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.
References
– [1]Shih C, et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57(6):1116-23.|[2]Anraku M, et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma. J Immunol. 2010 Jul 15;185(2):956-66.
CAS Number
– 150399-23-8
Molecular Weight
– 471.37
Compound Purity
– 99.99
SMILES
– O=C1NC(N)=NC2=C1C(CCC3=CC=C(C=C3)C(N[C@@H](CCC(O[Na])=O)C(O[Na])=O)=O)=CN2
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– H2O : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Antifolate;Apoptosis;Autophagy
Pathway
– Apoptosis;Autophagy;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
