Panobinostat
CgoaEGayGjuERhMfAAAAAASaotw148- Immunomart
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Panobinostat

SKU T2383-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 51 CAD through 613 CAD

Products Details

Product Description

– Panobinostat (NVP-LBH589) is a broad-spectrum HDAC inhibitor (IC50=5 nM) with oral activity and non-selectivity. Panobinostat has antitumor activity and induces apoptosis and autophagy.

Web ID

– T2383

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C21H23N3O2

Citations

– 1. Wellinger L C, Hogg S J, Newman D M, et al. BET Inhibition Enhances TNF Mediated Anti-Tumor Immunity. Cancer Immunology Research. 2022, 10(1): 87-107. 2. Wellinger L C, Hogg S J, Newman D M, et al. Bet inhibition enhances TNF-mediated antitumor immunity. Cancer Immunology Research. 2022, 10(1): 87-107 3. Juárez-Mercado K E, Prieto-Martínez F D, Sánchez-Cruz N, et al. Expanding the Structural Diversity of DNA Methyltransferase Inhibitors. Pharmaceuticals. 2021, 14(1): 17. 4. Zhao F, Huang Y, Zhang Y, et al. SQLE inhibition suppresses the development of pancreatic ductal adenocarcinoma and enhances its sensitivity to chemotherapeutic agents in vitro. Molecular Biology Reports. 2022: 1-9 5. Han L, Song B, Zhang P, et al.PC3T: a signature-driven predictor of chemical compounds for cellular transition.Communications Biology.2023, 6(1): 989. 6. Ma G, Gao A, Chen J, et al.Modeling high-risk Wilms tumors enables the discovery of therapeutic vulnerability.Cell Reports Medicine.2024 7. In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma

References

– Crisanti MC, et al. The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer. Mol Cancer Ther. 2009 Aug;8(8):2221-31.

CAS Number

– 404950-80-7

Molecular Weight

– C21H23N3O2

Compound Purity

– 0.9914

SMILES

– Cc1[nH]c2ccccc2c1CCNCc1ccc(C=CC(=O)NO)cc1

Pathway

– Autophagy|||Apoptosis|||Microbiology/Virology|||Chromatin/Epigenetic|||DNA Damage/DNA Repair|||Proteases/Proteasome

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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