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Paclitaxel
Price range: 54 CAD through 277 CAD
Products Details
Product Description
– Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.
Web ID
– T0968
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C47H51NO14
Citations
– 1. Gritsina G, Fong K, Lu X, et al.Chemokine receptor CXCR7 activates AURKA and promotes neuroendocrine prostate cancer growth.The Journal of Clinical Investigation.2023
2. Zhao X, Lian X, Xie J, et al.Accumulated cholesterol protects tumours from elevated lipid peroxidation in the microenvironment.Redox Biology.2023: 102678.
3. Zhu X, Huang N, Ji Y, et al.Brusatol induces ferroptosis in oesophageal squamous cell carcinoma by repressing GSH synthesis and increasing the labile iron pool via inhibition of the NRF2 pathway.Biomedicine & Pharmacotherapy.2023, 167: 115567.
4. Hou Z, Lin S, Du T, et al.S-72, a Novel Orally Available Tubulin Inhibitor, Overcomes Paclitaxel Resistance via Inactivation of the STING Pathway in Breast Cancer.Pharmaceuticals.2023, 16(5): 749.
5. Zhan Y, Chen Q, Song Y, et al. Berbamine Hydrochloride inhibits lysosomal acidification by activating Nox2 to potentiate chemotherapy-induced apoptosis via the ROS-MAPK pathway in human lung carcinoma cells. Cell Biology and Toxicology. 2022: 1-21
6. Pang G, Zhang S, Zhou X, et al. Immunoactive polysaccharide functionalized gold nanocomposites promote dendritic cell stimulation and antitumor effects. Nanomedicine. 2019 May;14(10):1291-1306
7. Sun J, Liu W, Li Y, et al. An on-chip cell culturing and combinatorial drug screening system. Microfluidics and Nanofluidics. 2017 Jul 21(7): 125.
8. ZeZhanga,b,c VLM catecholaminergic neurons control tumor growth by regulating CD8+ T cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020
9. Song X, Li D, Gan L, et al.Intravenous Injection of Na Ions Aggravates Ang II-Induced Hypertension-Related Vascular Endothelial Injury by Increasing Transmembrane Osmotic Pressure.International Journal of Nanomedicine.2023: 7505-7521.
10. Zeng L, Lyu X, Yuan J, et al.STMN1 Promotes Tumor Metastasis in Non-small Cell Lung Cancer Through Microtubule-dependent And Nonmicrotubule-dependent Pathways.International Journal of Biological Sciences.2024, 20(4): 1509.
References
– Park SJ, et al. Taxol induces caspase-10-dependent apoptosis. J Biol Chem. 2004 Dec 3;279(49):51057-67.
CAS Number
– 33069-62-4
Molecular Weight
– C47H51NO14
Compound Purity
– 0.9992
SMILES
– CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c1ccccc1)c1ccccc1
Target
– Others
Pathway
– Apoptosis|||Cytoskeletal Signaling|||Autophagy|||Antibody-drug Conjugate/ADC Related
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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