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Products Details
Product Description
– PAA5 is a methide carbon-centered polynuclear Au(I) cluster. PAA5 can release Au(I) causing Pro-oxidant response and accelerated ferroptosis. PAA5 increases the expression of pH2AX in a time-dependent manner. PAA5 has anticancer activity[1].
Web ID
– HY-149036
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C14H8Au5B2F8N
References
– [1]Xiao K, et, al. Pro-oxidant response and accelerated ferroptosis caused by synergetic Au(I) release in hypercarbon-centered gold(I) cluster prodrugs. Nat Commun. 2022 Aug 9;13(1):4669.
Molecular Weight
– 1348.66
SMILES
– [F-][B+3]([F-])([F-])[F-].[F-][B+3]([F-])([F-])[F-].C1(C(C234[Au@@]56[Au@]27[Au]358[Au]46)=[N]([Au]78)C9=C%10C=CC=C9)=C%10C=CC=C1.[2+]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite;Ferroptosis;Reactive Oxygen Species
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
