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P32/98 (hemifumarate)

SKU HY-129736-1mg Category Reference compound Tags Dipeptidyl Peptidase, Metabolic Disease, Metabolic Enzyme/Protease

$115

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Products Details

Product Description

– P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a Ki value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model[1][2][3].

Web ID

– HY-129736

Shipping

– Room temperature

Applications

– Metabolism-sugar/lipid metabolism

Molecular Formula

– C9H18N2OS.1/2C4H4O4

References

– [1]Augstein P, et al. Efficacy of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide (P32/98) in fatty Zucker rats with incipient and manifest impaired glucose tolerance. Diabetes Obes Metab. 2008;10(10):850-861. |[2]Schlatter P, et al. Glucagon-like peptide 1 receptor expression in primary porcine proximal tubular cells. Regul Pept. 2007 Jun 7;141(1-3):120-8. |[3]Wargent E, et al. Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone. Diabetes Obes Metab. 2005;7(2):170-181.

CAS Number

– 251572-86-8

Molecular Weight

– 260.36

SMILES

– CC[C@H](C)[C@H](N)C(N1CSCC1)=O.O=C(O)/C=C/C(O)=O.[1/2]

Clinical Information

– No Development Reported

Research Area

– Metabolic Disease

Solubility

– 10 mM in DMSO

Target

– Dipeptidyl Peptidase

Isoform

– DPP-4

Pathway

– Metabolic Enzyme/Protease

Product type

– Reference compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.