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Products Details
Product Description
– P32/98 a potent inhibitor of dipeptidyl peptidase IV with a Ki value of 130 nM. P32/98 improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model[1][2][3].
Web ID
– HY-129736A
Shipping
– Room temperature
Molecular Formula
– C9H18N2OS
References
– [1]Schlatter P, et al. Glucagon-like peptide 1 receptor expression in primary porcine proximal tubular cells. Regul Pept. 2007 Jun 7;141(1-3):120-8. |[2]Augstein P, et al. Efficacy of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide (P32/98) in fatty Zucker rats with incipient and manifest impaired glucose tolerance. Diabetes Obes Metab. 2008;10(10):850-861. |[3]Wargent E, et al. Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone. Diabetes Obes Metab. 2005;7(2):170-181.
CAS Number
– 136259-20-6
Molecular Weight
– 202.32
SMILES
– CC[C@H](C)[C@H](N)C(N1CSCC1)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Dipeptidyl Peptidase
Isoform
– DPP-4
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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