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Products Details
Product Description
– OTS186935 is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 regulates the production of γ-H2AX in cancer cells[1].
Web ID
– HY-122181
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H26ClN5O2
References
– [1]Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9(61):31820-31831.
CAS Number
– 2093400-18-9
Molecular Weight
– 463.96
SMILES
– COC1=C(Cl)C=C(C2=CN3C=CC(N4C[C@@H](NCC5=CC=NC=C5)CC4)=CC3=N2)C(OC)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Histone Methyltransferase
Isoform
– SUV39H2/KMT1B
Pathway
– Epigenetics
Product type
– Reference compound
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