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ON 146040
$300 – $480
Products Details
Product Description
– ON 146040 is a potent PI3Kα and PI3Kδ (IC50≈14 and 20 nM, respectively) inhibitor. ON 146040 also inhibits Abl1 (IC50<150 nM).
Web ID
– HY-12338
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C24H23N7O3S
References
– [1]Targeting oncogenic STAT3 and STAT5 signaling with on 146040, a small molecule inhibitor of PI3K α/δ and BCR-ABL.
CAS Number
– 1404231-34-0
Molecular Weight
– 489.55
Compound Purity
– 95.05
SMILES
– CN(CC1)CCN1C(C=C2)=CC=C2NC3=NC(S/C(C(N4)=O)=CC5=CC=C([N+]([O-])=O)C=C5)=C4C=N3
Clinical Information
– No Development Reported
Research Area
– Cancer
Target
– Bcr-Abl;PI3K
Isoform
– PI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
Pathway
– PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
