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NVP-TNKS656
$100 – $2,430
Products Details
Product Description
– NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM, and is > 300 fold selectivity against PARP1 and PARP2.
Web ID
– HY-13990
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H34N4O5
References
– [1]Shultz MD, et al. Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor. J Med Chem. 2013 Aug 22;56(16):6495-511.
CAS Number
– 1419949-20-4
Molecular Weight
– 494.58
Compound Purity
– 99.31
SMILES
– O=C(N(CC1CC1)CC2=NC3=C(COCC3)C(N2)=O)CN4CCC(C(C5=CC=C(OC)C=C5)=O)CC4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 40 mg/mL
Target
– Apoptosis;PARP
Isoform
– PARP2;TNKS2/PARP5B
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
