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Numidargistat
$100 – $450
Products Details
Product Description
– Numidargistat (CB-1158) is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent[1].
Web ID
– HY-101979
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C11H22BN3O5
Citations
– Biomed Pharmacother. 2022 Jun 24;153:113321.|Research Square Preprint. 2022 Mar.|bioRxiv. 2023 Sep 10.|Cancer Lett. 2023 May 5;216208.|Cell Commun Signal. 2023 Sep 18;21(1):236.|J Physiol. 2020 Nov;598(21):4907-4925.
References
– [1]Steggerda SM, et al. Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. J Immunother Cancer. 2017 Dec 19;5(1):101.
CAS Number
– 2095732-06-0
Molecular Weight
– 287.12
Compound Purity
– 98.0
SMILES
– O=C([C@@H](N)C)N1C[C@H](CCCB(O)O)[C@](N)(C(O)=O)C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Arginase
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
