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NSC59984
$80 – $720
Products Details
Product Description
– NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway[1]. NSC59984 acts by targeting GOF-mutant p53 and stimulates p73 to restore the p53 pathway signaling[2].
Web ID
– HY-19726
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C12H15N3O4
References
– [1]Zhang S, et al. Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53. Cancer Res. 2015 Sep 15;75(18):3842-52.|[2]Zhang S, et al. Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects againstColorectal Cancer via p73 Activation and Degradation of Mutant p53. Cancer Res. 2015 Sep 15;75(18):3842-52.
CAS Number
– 803647-40-7
Molecular Weight
– 265.27
Compound Purity
– 99.74
SMILES
– O=C(N1CCN(C)CC1)/C=C/C2=CC=C([N+]([O-])=O)O2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 38 mg/mL
Target
– MDM-2/p53
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
