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Navitoclax
$50 – $250
Products Details
Product Description
– Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM[1].
Web ID
– HY-10087
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C47H55ClF3N5O6S3
References
– [1]Chen J, et al. The Bcl-2/Bcl-X(L)/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo. Mol Cancer Ther. 2011 Dec;10(12):2340-9.|[2]Lock R1, et al. Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2008 Jun;50(6):1181-1189.|[3]Wong M, et al. Navitoclax (ABT-263) reduces Bcl-x(L)-mediated chemoresistance in ovarian cancer models.Mol Cancer Ther. 2012 Apr;11(4):1026-1035.
CAS Number
– 923564-51-6
Molecular Weight
– 974.61
Compound Purity
– 99.97
SMILES
– O=S(C1=CC(S(NC(C2=CC=C(N3CCN(CC4=C(CCC(C)(C4)C)C5=CC=C(Cl)C=C5)CC3)C=C2)=O)(=O)=O)=CC=C1N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)(C(F)(F)F)=O
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– DMF : ≥ 100 mg/mL|DMSO : 75 mg/mL (ultrasonic)
Target
– Bcl-2 Family
Isoform
– Bcl-2;Bcl-W;Bcl-xL
Pathway
– Apoptosis
Product type
– Reference compound
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