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MMAF (hydrochloride)
$50 – $240
Products Details
Product Description
– MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A[1][2][3].
Web ID
– HY-15579A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C39H66ClN5O8
Citations
– Oncol Rep. 2020 Dec 9.|J Control Release. 2018 May 10;277:48-56.|Mol Cancer Ther. 2023 Jan 31;MCT-22-0440.|Mol Ther Nucleic Acids. 2018 Mar 2;10:227-236.|Patent. US20210393733A1.|Research Square Preprint. 2023 Dec 4.|Research Square Print. 2023 Jan 6th.|Target Oncol. 2019 Oct;14(5):577-590.|University of Minnesota. 2022 Sep.
References
– [1]Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24.|[2]Lee JW, et al. EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma. Clin Cancer Res. 2010 May 1;16(9):2562-70.|[3]Lee JJ, et al. Enzymatic prenylation and oxime ligation for the synthesis of stable and homogeneous protein-drug conjugates for targeted therapy. Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12020-4.|[4]Kim EG, et al. Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted CancerTherapeutics.
CAS Number
– 1415246-68-2
Molecular Weight
– 768.42
Compound Purity
– 99.52
SMILES
– CC(C)[C@H](NC)C(N[C@H](C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)C)=O)C(C)C)=O.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 27 mg/mL (ultrasonic;warming)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– ADC Cytotoxin;Microtubule/Tubulin
Isoform
– Auristatin
Pathway
– Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Cytoskeleton
Product type
– ADC Related
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
