Products Details

Product Description

– MLKL-IN-1 is a covalent MLKL inhibitor with a KD of 50 μM.

Web ID

– HY-139878

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C19H20N2O3

References

– [1]Rübbelke M, et al. Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain. J Med Chem. 2021 Nov 11;64(21):15629-15638.

CAS Number

– 2837019-30-2

Molecular Weight

– 324.37

SMILES

– OC(C1=CC=C(N=C([C@@H](OC)C2=CC=C(C(C)C)C=C2)N3)C3=C1)=O

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology

Solubility

– 10 mM in DMSO

Target

– Mixed Lineage Kinase

Pathway

– MAPK/ERK Pathway

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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