Download Files:
ML359
$250 – $1,250
Products Details
Product Description
– ML359 is a potent, selctive and reversible inhibitor of protein disulfide isomerase (PDI), with an IC50 of 250 nM. ML359 can prevent thrombus formation in vivo[1][2].
Web ID
– HY-114086
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C23H28ClNO4
References
– [1]Khodier C, et, al. Identification of ML359 as a Small Molecule Inhibitor of Protein Disulfide Isomerase. Probe Reports from the NIH Molecular Libraries Program. 2010-2013 Apr 12.|[2]Bendapudi PK, et, al. ML359, a Small Molecule Inhibitor of Protein Disulfide Isomerase That Prevents Thrombus Formation and Inhibits Oxidoreductase but Not Transnitrosylase Activity. Blood (2014) 124 (21): 2880.
CAS Number
– 1069858-99-6
Molecular Weight
– 417.93
Compound Purity
– 99.08
SMILES
– O=C(C1(CCN(CC1)CC2=CC=C(C(Cl)=C2)O)CCOC3=CC=CC=C3)OCC
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– PDI
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
